Fresh analysis suggests that people who come off popular GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds far faster than those who end conventional lifestyle programs.
Research printed in a major health publication demonstrates that while obese people often shed about a fifth of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals buying these medications should be cognizant of the danger of quick rebound weight gain when the therapy concludes," warns researcher Dr. Susan Jebb.
That rate of regain suggests a return to original weight within about 18 months.
Analyzing Therapies
The analysis, which reviewed 37 of trials involving thousands of patients, compared the results of the injectable medications with older methods.
Scientists point out that people who shed pounds through dieting generally have a less rapid weight regain—perhaps 0.1 kg a month—post-intervention.
The Reason for the Quick Regain
Nutrition scientists suggest the mechanism of the injections explains the amplified weight return.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Artificially providing GLP-1 levels several times higher than normal could lead to the body to produce less of its own natural hormone, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Stopping of this hormone supplement results in hunger is unsuppressed, making overeating a significant risk."
An Ongoing Condition?
Health authorities suggest the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
Professionals argue that, due to the likelihood of relapse, the treatment should be considered ongoing.
This view is reinforced by drug manufacturers, who say that the findings "emphasize the long-term character of excess weight," comparing it to managing conditions like high blood pressure.
User Experiences
People who have come off the jabs describe a powerful resurgence of hunger.
"It felt as if something flipping and I was suddenly starving," said a patient.
The struggle is worsened if individuals have not adopted lasting lifestyle or habit changes during therapy.
Widespread Adoption
Recent estimates indicate that a significant number of adults in the UK have used these injections in the last 12 months, with interest being substantial.
- Adoption is higher among women compared to males.
- The middle-aged age group shows the greatest level of interest.
- Many access the medications through private prescriptions rather than public health services.
Ultimately, researchers stress that while these medications are potent agents for shedding pounds, they are not a permanent solution and long-term success hinges on combined behavioural changes.
